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Herpes simplex virus type 1 HSV1 is widely used as a gene delivery vector in a variety of laboratory animals. In a recent study, a thymidine-kinase-inactive replication-conditional HSV1 used as a delivery vector was lethal in naked mole rats, whereas mice infected with the identical virus showed no adverse effects. This result prompted us to undertake a controlled comparative histologic study of the effect of HSV1 infection on naked mole rats and mice. Replication-competent and replication-conditional HSV1 caused widespread inflammation and necrosis in multiple organ systems of naked mole rats but not mice; naked mole rats infected with replication-defective virus showed no adverse effects. We conclude that the lethality of HSV1 for naked mole rats is likely the result of overwhelming infection, possibly in part due to this species' natural lack of proinflammatory neuropeptides at the initial site of infection. Abstract Herpes simplex virus type 1 HSV1 is widely used as a gene delivery vector in a variety of laboratory animals.
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Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Neuroreport , 01 Dec , 20 18 : DOI: Read article at publisher's site DOI : Subscription required at www.
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